Table 3.
The Association of Aldosterone with Incident Diabetes and the Mediational Role of Blood Pressure and Fasting Glucose.
| Hazard Ratio (95% CI) | p-valuea | |
|---|---|---|
| Per 1-unit increase in log-Aldosterone | 1.44 (1.25, 1.64) | <0.001 |
| Percentage mediated (%) | p-valueb | |
|---|---|---|
| Blood Pressure (Mediator) | 16.3 (7.0, 31.0) | <0.001 |
| Fasting Glucose (Mediator) | 19.7 (6.5, 34.0) | 0.002 |
Adjusted for age, sex, education, occupation, alcohol use and eGFR.
a
p-value is obtained using Cox proportional hazards model.
b
p-values are obtained using mediation analysis
Interpretation:
A 1-unit increase in log-aldosterone was associated with a 44% higher risk of diabetes (p<0.001). The interpretation with conversion to aldosterone is a that a 10% higher aldosterone was associated with 3.5% higher risk of diabetes. 16.3% (p<0.001) of the effect of aldosterone on incident diabetes is mediated through blood pressure and 19.7% (p = 0.002) is mediated through fasting glucose.