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. 2023 Jan 4;120(2):e2210690120. doi: 10.1073/pnas.2210690120

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Copyright © 2023 the Author(s). Published by PNAS.

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Fig. 2. — YM-1 disrupts the VP40/BAG3/HSP70 complex and rescues VP40 VLP egress. (A) Diagram of YM-1 disrupting the VP40/BAG3/HSP70 complex. (B and C) Co-IP assay showing reduced levels of HSP70 and VP40 detected in BAG3 precipitates in the presence of YM-1 compared to DMSO control. (D–G) eVP40 and mVP40 VLP budding assays in HEK293T cells and VLP quantification (bar graphs from three independent experiments) in the absence (DMSO) or presence of YM-1. Statistical significance was analyzed by one-way ANOVA. ns: not significant, *P < 0.05, ***P < 0.001, ****P < 0.0001.