Figure 10.

Cemdomespib (Cmdespib) altered the foamy/nonfoamy M1 macrophage ratio in the sciatic nerve. (A) Representative images of foamy (yellow arrows) and nonfoamy (orange arrows) in vehicle- and cemdomespib-treated mice. (B) Quantification of total M1 macrophages in the sciatic nerve. Data are mean ± SEM and were analyzed with a one-way ANOVA and the Benjamini, Krieger, and Yekutieli test. (C) Quantification of foamy and nonfoamy macrophages in the sciatic nerve. *, p < 0.03 versus WT. Data are mean ± SEM and were analyzed using a two-way mixed-effect analysis and the Benjamini, Krieger, and Yekutieli test. Symbols indicate the response of individual animals in each group.