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. 2023 Jan 20;6(2):306–319. doi: 10.1021/acsptsci.2c00223

Figure 6.

Figure 6

Nine-month-old Cx32def, T55I-Cx32def, and R75W-Cx32 mice show an improved MNCV after 5 months of daily cemdomespib therapy. (A) *, p < 0.005 versus WT; ^, p < 0.002 versus 0 mg/kg; #, p < 0.0001 versus 0 mg/kg; ★, p < 0.0001 versus 0.3 mg/kg. (B) Cemdomespib only improved CMAP in Cx32def mice. *, p < 0.002 versus WT. Data for Cx32def and T55I-Cx32def were pooled from two independent cohorts of mice. Data are mean ± SD and were analyzed using a one-way ANOVA and Tukey’s test. Symbols indicate the response of individual animals in each group.