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. 2023 Jan 20;6(2):306–319. doi: 10.1021/acsptsci.2c00223

Figure 9.

Figure 9

Cemdomespib (Cmdespib) may improve NMJ degeneration. (A) Two representative examples of fully innervated NMJs in WT, largely denervated NMJs in untreated Cx32def mice, and partially denervated NMJs in Cx32def mice treated with cemdomespib. Line indicates the region used to assess the overlap of staining intensity of SV2 + NF and α-BGT as a marker for AchRs, and these data are shown in Supporting Figure 4A–C. (B) Quantification of the nerve terminal perimeter and area and the AchR perimeter and area by NMJ Morph. *, p < 0.03 versus WT. Data are mean ± SEM and were analyzed using a one-way ANOVA and Tukey’s test. Symbols indicate findings for individual animals in each group. (C) PCA of physiologic and morphologic measures suggest a drug effect since cemdomespib-treated animals clustered more closely with WT mice. The size of the circles shows a range of unoccupied AchR areas as an indication of the extent of NMJ innervation. Data were standardized to have a mean of 0 and an SD of 1 with principal components identified using a parallel analysis with 1000 Monte Carlo simulations and a random seed.