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. 2023 Feb 14;13:3. doi: 10.1186/s13395-023-00313-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The microcirculation regenerates through angiogenesis. A At 7 dpi, nascent microvessels emigrate centripetally from existing vasculature at wound edge. B At 7 dpi, microvessels are nonuniform in diameter and extend into the wound with random orientation. C Angiogenesis at 10 dpi is integral to revascularization. D Sites of robust angiogenic activity at 10 dpi create irregular microvascular plexuses. E Regenerating microvascular networks expand at 14 dpi. Images are from Cdh5-mTmG mice in which ECs are green (GFP) and all other cells are red (tdTomato)