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. 2023 Feb 14;13:3. doi: 10.1186/s13395-023-00313-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Tile scanned images showing the time course of microvascular and myofiber regeneration after punch biopsy. A At 7 dpi, angiogenesis begins around edges of wound. B At 14 dpi, regenerating microvessels have spanned the wound and myofibers have begun regenerating into the wound from severed ends. C At 21 dpi, myofibers traverse the wound while capillary networks remain disorganized. Dark areas within the regenerated area reflect interweaving among adjacent myofibers, which contrasts with the parallel (flat) organization of surrounding (uninjured) myofibers. Within the wound, microvessels remodel (arrowhead) to supply a cluster of adipocytes (not visible) where myofibers have not regenerated. D, E, and F are higher magnification of regions within broken yellow squares shown in A, B, and C to illustrate angiogenesis at the wound edge, microvascular branches extending across the gap, and microvascular remodeling around a cluster of adipocytes, respectively. Images are from Cdh5-mTmG mice in which ECs are green (GFP) and all other cells are red (tdTomato)