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. 2023 Feb 13;15:23. doi: 10.1186/s13148-023-01435-7

Fig. 1.

Fig. 1

Diagram of EWA and BC study populations from the WHI and TCGA cohorts. BC Breast cancer, CpGs CpG dinucleotide, DNAm DNA methylation, ER/PR + Estrogen receptor/progesterone receptor–positive, EWA Epigenome-wide association, HER2/neu– Human epidermal growth factor receptor-2–negative; TCGA The Cancer Genomic Atlas, WHI Women’s Health Initiative. * Individuals within Stage 2 had DNAm data measured at 2 visits and, for the analysis, the DNAm of those with a shorter interval between enrollment and blood draw were selected. ** Those selection criteria were applied to TCGA BC tissues. § The cases of HER2/neu– contained 49 (13% of BC cases) triple negatives