Fig. 6.

K9-C-peptide supplementation inhibits HGM-induced pulmonary vascular leakage and fibrosis in the lungs of HGM mice. HGM mice were implanted for 4 weeks with K9-C-peptide (HGM + K9-C-pep) or K8 polypeptide (HGM + K8) depots and then subjected to analysis of pulmonary vascular leakage and fibrosis. Pulmonary fibrosis was assessed by Sirius red and H&E staining. A Visualization of microvascular leakage using FITC-dextran in the mouse lungs of C57BL/6 and Tgm2.^−/− mice. Scale bar, 100 µm. B Representative images of lung tissues stained with Sirius red and H&E. Scale bar, 100 µm. C The positive area of Sirius red staining (n = 6). Statistical significance was determined by one-way ANOVA with Holm-Sidak’s multiple comparisons test. NS, non-significant. ***P < 0.001