Fig. 2.

Landscape of m⁷G RNA methylation regulators in HF. A Circus plot of chromosome distributions of the 29 m⁷G regulators. B protein–protein interaction (PPI) network among the 29 m⁷G RNA methylation regulators. C Correlations among the 24 m⁷G regulators in heart samples from HF patients and NFDs. A positive correlation is indicated by red, while a negative correlation is indicated by blue. D Expression profiles of m⁷G RNA methylation regulators between HF patients and NFDs. ns = not significant, *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the NFD group. E Volcano plot showing the differential expression of 14 m⁷G regulators between HF patients and NFDs. F Correlation analysis among 14 differentially expressed m⁷G regulators in HF patients. ☒ in red stands for nonsignificant at p < 0.05. The scatter plot demonstrated the m⁷G regulators pair with the highest differential correlation, WDR4 and AGO2 with the most positive correlation