Table 4.

HBIS positively correlated to EFC_4 and manually identified with MetaCyc database

Spearman correlation (adj. P-value < 0.05)
EC name	EC number	EFC_4	EFC_1	Related products effects	Ref
Spermidine synthase	2.5.1.16	0.764993	− 0.340411	Reduction in mortality due to cardiovascular disease	[42, 43]
Porphobilinogen synthase	4.2.1.24	0.590898	-	Heme biosynthesis	[44]
Mycothiol synthase	2.3.1.189	0.771842	− 0.319983	Antibacterial and antitumoral properties	[45, 46]
Hydrogenobyrinic acid a,c-diamide synthase	6.3.5.9	0.642982	− 0.284009	Coenzyme B12 (cobalamin) biosynthesis	[47, 48]
Cystathionine gamma-synthase	2.5.1.48	0.712590	− 0.256458	Energy metabolism, muscle performance, antioxidant	[49–54]
Glutamate synthase (NADPH)	1.4.1.13	0.623222	-	Excitatory neurotransmitter, homocysteine balance	[55–58]
Asparagine synthase	6.3.5.4	0.645870	-	Excitatory neurotransmitter, homocysteine balance	[55–58]
Glutaminyl-tRNA synthase	6.3.5.7	0.768508	− 0.284009	Excitatory neurotransmitter, homocysteine balance	[55–58]