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. 2023 Feb 14;22:54. doi: 10.1186/s12936-023-04483-9

Table 3.

Estimated parasite clearance half-lives (hours) by anti-malarial treatment administered using WWARN PCEa and Bayesian hierarchical modelling

Treatment WWARN PCEa Bayesian hierarchical modelling
Uncomplicated malaria
Artemether–lumefantrine (n) 301 320
 Mean (hours) 2.845 1.940
 Median (hours) 2.634 1.940
 95% CI & CrI (hours) [1.568, 5.254] [1.808, 2.116]
Artesunate–mefloquine (n) 111 115
 Mean (hours) 3.029 1.929
 Median (hours) 2.529 1.932
 95% CI & CrI (hours) [1.466, 7.683] [1.741, 2.137]
Chloroquine (n) 174 176
 Mean (hours) 3.599 2.861
 Median (hours) 3.265 2.865
 95% CI & CrI (hours) [1.867, 7.324] [2.689, 3.044]
Severe malaria
Artemether–lumefantrine followed by artesunate (intravenous) (n) 15 16
 Mean (hours) 2.485 1.970
 Median (hours) 2.118 1.961
 95% CI & CrI (hours) [1.513, 4.867] [1.622, 2.429]
Artesunate (intravenous) followed by artemether–lumefantrine (n) 77 87
 Mean (hours) 2.532 1.792
 Median (hours) 2.275 1.793
 95% CI & CrI (hours) [1.252, 4.181] [1.584, 2.009]

aWorldwide Antimalarial Resistance Network Parasite Clearance Estimator

CI: Confidence interval; CrI: Credible interval