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Postulated AOPs and AOP network. The increase in proliferation and the hormonal levels (e.g. including estrogen dominance and increase of estrogen levels) were identified as dominant/critical KEs and defined the possibility to develop an AOP network. The green (last) AOP refers to exposure to estrogenic chemicals (e.g. diethylstilbestrol (DES)) during early development (Suen et al., 2018)
