AOPs

AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction AOP 73: Xenobiotic Inhibition of Dopamine‐beta‐Hydroxylase and subsequent reduced fecundity AOP 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I/metaphase I transition AOP 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) AOP 126: Alpha‐noradrenergic antagonism leads to reduced fecundity via delayed ovulation AOP 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats AOP 167: Early‐life estrogen receptor activity leading to endometrial carcinoma in the mouse. AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. AOP 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. AOP 309: Luteinising hormone receptor antagonism leading to reproductive dysfunction AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction AOP 7: Aromatase reduction leading to impaired fertility

KEs/KERs

KEs related to GnRH and LH KE 530 decreased, GnRH pulsatility/release in AOP 73 xenobiotic inhibition of dopamine‐beta‐hydroxylase and subsequent reduced fecundity KE 530 decreased, GnRH pulsatility/release in AOP 126 alpha‐noradrenergic antagonism leads to reduced fecundity via delayed ovulation KE 969 decreased GnRH release, decreased kisspeptin stimulation of gnrh neurons in AOP 153 aromatase inhibition leading to ovulation inhibition and decreased fertility in female rats KE 1071 decreased, GnRH pulsatility/release in hypothalamus in AOP 169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the sd rat. KE 1071 decreased, GnRH pulsatility/release in hypothalamus in AOP 168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the sd rat. KE 690 Reduced, Luteinising hormone (LH), plasma KE 971 Ovulation of oocytes reduced, delayed or blocked, Decrease or delay in LH surge required for ovulation KE 531 Decreased, LH Surge in AOP 126 Alpha‐noradrenergic antagonism leads to reduced fecundity via delayed ovulation KE 1072 Decreased, LH Surge from anterior pituitary in AOP 168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. KE 970 Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs in AOP 153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats KE 129 Reduction, Gonadotropins, circulating concentrations KEs and KERs related to ovulation and oestrus cyclicity KE 1073 anovulation, KE 488 Decrease, Ovulation KE 532 Delayed, Ovulation KE 1695 Impaired ovulation KE 1989 Impaired, Oocyte maturation and ovulation KE 1074 Interruption, Ovulation KER 1110‐Decreased, LH Surge from anterior pituitary leads to prolonged, estrus KER: 1111 prolonged, oestrus leads to Increased, circulating estrogen levels KEs related to estrogen receptor KE 1181 Activation, Estrogen receptor KE 1065 Activation, estrogen receptor alpha KE 111 Agonism, Estrogen receptor KE 1984 Agonism, Estrogen Receptor alpha KE 112 Antagonism, Estrogen receptor KE1710 Binding to estrogen receptor (ER)‐α in immune cells KE 1180 Estrogen receptor activation, KE 748 Increased, Estrogen receptor (ER) activity KE 1064 prepubertal increase, Estrogen receptor (ER) activity KE 1046 Suppression, Estrogen receptor (ER) activity