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. 2023 Feb 14;8:18. doi: 10.1038/s41541-023-00610-4

Fig. 6. Immunization with CMS-adjuvanted RBD nanoparticles induces cross-neutralizing antibodies.

Fig. 6

Young (3-month-old) and aged (14-month-old) BALB/c mice were immunized on Day 0 (prime) and 14 (boost) with 0.3 µg of RBD nanoparticle (RBD-NP) formulated with AddaVax, AddaS03, CMS adjuvant or AS01B. Serum samples were collected on Day 28 to assess neutralizing titers (NT50) against SARS-CoV-2 wild type (WT), B.1.1.7 or B.1.351 pseudoviruses. Dotted lines indicate a lower limit of detection. N = 5 mice per group and each dot represent an individual sample. Numbers indicate geometric mean titers for each experimental group. Source data are provided as Supplementary Data.