. 2022 Dec 8;11(1):e02256-22. doi: 10.1128/spectrum.02256-22

TABLE 1.

Cytokine and expression quantitative trait loci of glutamine metabolism genes^a

Gene	SNPs	cQTLs				eQTLs	Gene function
Gene	SNPs	IL-22	IFN-γ	TNF	IL-6	eQTLs	Gene function
GCLM	rs4598495	0.034				3.01E-08	Converts l-cysteine and l-glutamate to glutathione
GFPT1	rs62134901		0.010			3.88E-83	Converts l-glutamine to l-glutamate and d-fructose-6-phosphate to d-glucosamine-6-phosphate
GFPT1	rs66693186			0.016		7.85E-232
GFPT2	rs77017168			0.030		4.25E-16
GLS2	rs7302925	0.037				1.47E-05	Converts glutamine to glutamate
GLUL	rs2924458	0.012				7.35E-13	Converts l-glutamate to l-glutamine
GOT2	rs1473206		0.024			4.40E-161	Converts l-aspartate to l-glutamate
GOT2	rs8058982	0.011				1.96E-41	Converts l-aspartate to l-glutamate
SLC1A5	rs314660				0.017	1.49E-05	High-affinity glutamine transporter
SLC7A5	rs11117336		6.80E-05			5.29E-14	Antiporter; exchanges intracellular glutamine for extracellular leucine
	rs11117336	1.71E-06				5.29E-14
	rs4264398			0.018		2.59E-07

SNP, single-nucleotide polymorphism; QTLs, quantitative trait loci; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor. P values for cytokine QTLs were obtained after correcting for age, gender, and cell counts. Only data with a nominal P value <0.05 are shown.