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. 2023 Jan 11;11(1):e03177-22. doi: 10.1128/spectrum.03177-22

TABLE 5.

Comparison of the qPCR and ddPCR approaches for SARS-CoV-2 detection

Criterium qPCR ddPCR
Platform tested QuantStudio Flex 6 384 platform (Applied Biosystems, Inc., USA) QX200 Droplet Digital PCR System (Bio-Rad Laboratories, USA)
Samples / run 184 94
Run time 1.5 hours (1 step) 1 day (3 steps)
Quantification type Relative to standards Absolute
Quantification range 3 to 1,000,000 copies/reaction 5 to 15,000 copies/reaction
Equipment cost £37,000 £110,000
Reagent cost/90 samples £445 £520 to 600
Sample vol/reaction 4 μL 10 μL
Amplicon sequencing Yes No