Figure 6.

The FOXA family plays a role in multiple stages of life. FOXA1 and FOXA2 play a major role in the phase of liver and spleen development. The role of the FOXA family for glucose metabolism and lipid metabolism is well established (solid line), and altered FOXA expression has been shown in the liver of both patients and animal models of NAFLD, and some of these alterations have been proven to have impact on the pathogenesis of NAFLD (dashed line). In older age, mainly FOXA2 and FOXA3 dominate the development of age-related obesity.