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IBG restores the sensitivity of colistin against Gram-negative bacteria. (A) Chemical structure of the IBG. The guanidine group is marked in red. (B) Inhibition rate of colistin combined with IBG against 30 Gram-negative bacteria. (C and D) Time-kill assays conducted with colistin (0.5× MIC), IBG monotherapy (10 μg/mL), the combination, or later addition of colistin or IBG against colistin-susceptible E. coli ATCC 25922 (C) and colistin-resistant E. coli SHP45 (D).
