FIG 6.

Efficacy of IBG combined with colistin in vivo. (A) Scheme of the experimental protocol for three animal models. (B) Survival rates of the G. mellonella larvae (10 per group) infected by E. coli SHP45 undergoing treatment with IBG (40 μg/mL) or colistin (2 μg/mL) alone or in combination (10 μg/mL IBG + 1 μg/mL colistin or 40 μg/mL IBG + 2 μg/mL colistin). (C) Survival rates of female BALB/c mice (6 per group) infected by E. coli SHP45 in the mouse peritonitis-sepsis model treated with a single dose of IBG (40 μg/mL) or colistin (2 μg/mL) alone or with IBG plus colistin (10 μg/mL + 1 μg/mL or 40 μg/mL + 2 μg/mL). (D) Bacterial loads in infected thigh muscle in mice (6 per group). P values were determined using nonparametric one-way ANOVA. Data are means and SD.