TABLE 1.
Antibacterial activity of IBGa
| Strain | Source | mcr-1 | MIC (μg/mL) |
FICI | Effect | |
|---|---|---|---|---|---|---|
| Colistin | IBG | |||||
| Gram-positive bacteria | ||||||
| S. aureus ATCC 29213 | Reference strain | − | 4 | |||
| E. faecalis ATCC 29212 | Reference strain | − | 4 | |||
| Gram-negative bacteria | ||||||
| Escherichia coli | ||||||
| ATCC 25922 | Reference strain | − | 0.5 | >2,560 | 0.12 | Synergy |
| GDQ8D43 | Pig | + | 2 | >2,560 | 0.12 | Synergy |
| SHPP45 | Pig | + | 4 | >2,560 | 0.12 | Synergy |
| GDQ8P37 | Pig | + | 4 | >2,560 | 0.06 | Synergy |
| Salmonella | ||||||
| ATCC 14028 | Reference strain | − | 0.5 | >2,560 | 0.12 | Synergy |
| S226 | Chicken | + | 2 | >2,560 | 0.06 | Synergy |
| S235 | Pig | + | 2 | >2,560 | 0.12 | Synergy |
| 26FS14 | Pig | + | 2 | >2,560 | 0.25 | Synergy |
| Klebsiella pneumoniae | ||||||
| ATCC 700603 | Reference strain | − | 1 | >2,560 | 0.25 | Synergy |
| MPC11 | Pig | − | 0.5 | >2,560 | 0.25 | Synergy |
| MPC11+ pHNSHP45 | Pig | + | 8 | >2,560 | 0.12 | Synergy |
| 117 | Pig | + | 16 | >2,560 | 0.25 | Synergy |
| 281 | Pig | + | 16 | >2,560 | 0.25 | Synergy |
| Acinetobacter baumannii | ||||||
| ATCC 19606 | Reference strain | − | 1 | >2,560 | 0.25 | Synergy |
| 130939 | Human | − | 2 | >2,560 | 0.12 | Synergy |
| 131284 | Human | − | 4 | >2,560 | 0.12 | Synergy |
| Pasteurella multocida | ||||||
| 399 | CVCC | − | 2 | >2,560 | 0.06 | Synergy |
| 434 | CVCC | − | 4 | >2,560 | 0.03 | Synergy |
| 89 | Pig | − | 0.5 | >2,560 | 0.06 | Synergy |
| 23 | Pig | − | 0.5 | >2,560 | 0.03 | Synergy |
a
ATCC, American Type Culture Collection; CVCC, China Veterinary Culture Collection Center; FICI, fractional inhibitory concentration index, observed in three independent experiments.