FIG 4.

CBX5 is a functional target of sRNA45033 involved in hPDLC apoptosis. (A) Transcriptome sequencing analysis of hPDLCs administered P. gingivalis OMVs; (B) relative expression of msRNA in P. gingivalis OMVs; (C) possible target screening of sRNA45033; (D and E) CBX5 expression of hPDLCs treated with LPS or OMVs; (F and G) CBX5 immunochemistry analysis of the CTRL group, CP group, OMVs group, and CP+OMVs group. The positive areas in four independently chosen fields were counted and averaged. Data are shown as mean ± SD. Data between two groups were compared using Student's t test. Cell experiments were conducted three times independently. *, P < 0.05; **, P < 0.01.