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Structures of DAR A, DAR B, and newly designed DAR B9 and bioactivity against Gram-negative indicator strains. Distinguishing features of darobactin B are serine replacements by threonine and arginine at positions 4 and 6, respectively. In darobactin B9, phenylalanine is additionally replaced by tryptophan at the C-terminal position of the heptapeptide. DAR B and DAR B9 exhibit pronounced activity against the test panel. Data for DAR A and DAR B were obtained from previous studies.
