TABLE 3.
Results of antimicrobial susceptibility testing with darobactin B and darobactin B9 for 66 P. aeruginosa isolates stratified by MRGNa classification
| Total or MRGNa type (n) | MIC50b |
MIC90b |
||
|---|---|---|---|---|
| DAR B | DAR B9 | DAR B | DAR B9 | |
| Total (66) | 8 | 8 | 8 | 16 |
| Non-MRGN (18) | 8 | 8 | 8 | 8 |
| 3-MRGN (10) | 8 | 8 | 8 | 16 |
| 4-MRGN (38) | 8 | 8 | 16 | 16 |
a
MRGN (multidrug-resistant Gram-negative) bacteria are classified according to KRINKO as unsusceptible to the lead compounds of 3 (3-MRGN) or 4 (4-MRGN) of the following antibiotic classes: acyl ureidopenicillins (piperacillin-tazobactam or piperacillin), third- or fourth-generation cephalosporins (ceftazidime and cefepime), fluoroquinolones (ciprofloxacin), and carbapenems (meropenem and imipenem).
b
MIC50/90 is defined as the MIC in micrograms per milliliter at which 50%/90% of isolates were inhibited, respectively (12).