Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 31;14:1053550. doi: 10.3389/fimmu.2023.1053550

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Panigaj, Skelly, Beasock, Marriott, Johnson, Salotti and Afonin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

During contact with stromal fibroblasts, breast cancer cells activate NOTCH1/MYC signaling that leads to higher transcription of ncRNA RN7SL1 carrying 5’-ppp. These transcripts then remain unshielded since levels of their protein-binding partner (SRP9/14) remain constant. Naked RN7SL1 is loaded to exosomes and, upon interaction with breast cancer cells, can activate RIG-I signaling leading to an inflammatory tumor microenvironment that can promote tumor progression and poor clinical outcomes.