TABLE 6.

Penetration of IVA in ELF and lungs^a

Mouse group	PK value by sample type						PK ratiosb
	Plasma		Lung		ELF		Lung/plasma		ELF/plasma
	fCmax (ng/mL)	fAUC (h·ng/mL)	fCmax (ng/mL)	fAUC (h·ng/mL)	Cmax (ng/mL)	AUC (h·ng/mL)	C max	AUC	C max	AUC
Non-infected	0.70	2.20	0.65	2.44	537	1,910	0.93	1.11	767	868
Infected	0.29	2.72	0.94	10.62	981	2,587	3.24	3.90	3,383	951

^aThe C_max and AUC of plasma and lung homogenates were corrected for the free fraction according to the results of the protein binding experiment (0.03% for plasma and 0.26% for lung; see Table 4) to obtain the C_max and AUC of unbound IVA (fC_max and fAUC). Data are the geometric means of values from 3 to 4 mice.

^bLung/plasma values are the ratio of lung free maximum concentration or lung exposure to free maximum concentration divided by those in plasma, and ELF/plasma values are the ratio of ELF maximum concentration or ELF exposure to maximum concentration divided by plasma free maximum concentration or plasma exposure to free maximum concentration. fC_max and fAUC refer to unbound IVA in the plasma and lung.