Fig. 4.

Simultaneous MBTA therapy in the right and left parallel Panc02 tumors and irradiation of the left parallel tumor. a C57BL/6 mice were subcutaneously injected with Panc02 cells in both right and left flanks. After 12 days, mice were randomized into 5 groups (n = 6/group): the group treated with MBTA therapy (right and left tumor); the group treated with MBTA therapy (right tumor) and PBS (left tumor); the group treated with MBTA therapy (right tumor) and radiotherapy (RT) (left tumor); the group treated with PBS (right tumor) and RT (left tumor); the group treated with PBS (both tumors). Therapy was given intratumorally into the right or left parallel tumor on days 0, 1, 2, 8, 9, 10, 16, 17, 18, 24, 25, and 26. The left parallel tumors were irradiated on days 0, 14, and 28. The tumor volume of both tumors was measured with a caliper. b The tumor volume growth of the right MBTA-treated and (c) the left parallel-treated tumors is presented as a growth curve (*p < 0.05, **p < 0.01, ***p < 0.005, *****p < 0.0005). d The survival analysis is presented as a Kaplan–Meier curve (*p < 0.05, **p < 0.01)