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. 2023 Jan 31;13:1064095. doi: 10.3389/fmicb.2022.1064095

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Copyright © 2023 Dove, Dzurny, Dees, Qin, Nunez Rodriguez, Alt, Ellward, Best, Rudawski, Fujii and Czyż.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Checkerboard analysis of AgNP and amikacin combination against MDR E. coli. A dose–response combination of AgNPs with amikacin was tested against (A) E. coli 0494, amikacin-sensitive strain and (B) E. coli 0346, amikacin-resistant strain. The checkerboard represents an average of three independent experiments. The FICI for the amikacin-sensitive strain indicates a partial synergy. See Methods 2.3 for details. FICI = FIC_AgNP + FIC_Amikacin; FIC_AgNP = MIC_AgNP combination/MIC_AgNP alone; FIC_Amikacin = MIC_Amikacin combination/MIC_Amikacin alone. ΣFICI = (0.755/1.55) + (0.25/8.0) = 0.52.