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[Preprint]. 2023 Jun 17:2023.01.26.525745. Originally published 2023 Jan 26. [Version 2] doi: 10.1101/2023.01.26.525745

Figure 3. MR hormone response in the presence or absence of GR.

Figure 3.

A. Venn diagrams of hormone-regulated protein-coding genes (2 Hrs. treatment/vehicle) to 100nM Cort or 10nM Aldo. Total number of hormone responsive genes (FDR ≤ 0.01, Log2 FC ≥ +/− 0.5) denoted in parentheses for MR expressing GRKO cells, MR expressing Parental cells or Parental cells without MR. Circles connected with lines denote 11 common hormone-responsive genes to the two cell lines. B. Scatter plot of Log2 FC for 30 genes common (meet FDR 0.01 cutoff only) to the four denoted conditions. Box and whiskers plot of the same data display interquartile range (IQR) depicting the 25th, 50th and 75th percentile as box with the median as black bar. The whiskers mark the most induced and repressed genes.