Table 2.

PROs measures included in trial

Measures	Description	Clinical Cut-Offs
Primary
PRO-CTCAEs19	5 items (related to VR use) with option to add items, 5-point Likert scale or 0/1 for absent/present	1 = mild 2 = moderate 3 = severe 4 = life-threatening 5 = death
Secondary
NCCN Distress Thermometer20	1 item, 11-point Likert scale with accompanying Problem List	≥ 5 = moderate-severe
STAI-6 (S-scale)21,22	6 items from S-scale, 4-item Likert scale (total score converted to range from 20 to 80)	≥ 40 = clinically significant
Exploratory
UCLA Loneliness Scale23,24	20 items, 4-point Likert scale	20 to 34 = low 35 to 49 = moderate 50 to 64 = moderately high 65 to 80 = high
COST Questionnaire25	11 items, 5-point Likert scale	not established
ADNM-2026	Stressor & Item lists, 4-point Likert scale	≥ 47.5 = high risk

Abbreviations: PRO-CTCAEs: Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events; AE: adverse event; STAI-6: State-Trait Anxiety Inventory 6-item; S-scale: “state” anxiety subscale of STAI-6; UCLA: University of California – Los Angeles; COST: Comprehensive Score for Financial Toxicity; ADNM-20: Adjustment Disorder New Module – 20