Figure 2.

Self-administration of toluene vapor by rats. A) Schematic shows setup of vapor inhalation chamber with active and inactive nosepokes and vaporizers supplying toluene vapor. Entry into the active nosepoke delivers 15 sec of toluene vapor from vaporizers. Traces below show examples of toluene vapor self-administration by different animals with vapor concentration (ppm) on the y-axis and session time (sec) on the x-axis. Open circles indicate toluene vapor concentration during the session with red-filled circles indicating active nosepokes. B) Daily average of self-administration of toluene or air (mean ± SEM). C) Time course of self-administration of toluene or air during a 1 hr session. Data are mean (± SEM) from the last week of self-administration. Figure adapted from Braunscheidel et al., 2020 and used with permission.