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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Addict Neurosci. 2022 Dec 22;5:100059. doi: 10.1016/j.addicn.2022.100059

Figure 3.

Figure 3.

Effects of toluene vapor on decision making by male and female rats during a probabilistic risk task. Top panel show performance of males (top) and females (bottom) on (A) proportion of risky choice during descending odds protocol; (B) proportion of risky choice after risky win (“Win-Stay”); (C) proportion of safe choice after risky loss (“Lose-Shift”); (D) choice latency after cue; (E) omissions. Data are mean ± SEM. Changes in mPFC neuronal calcium measured by GCaMP6f fiber photometry during probabilistic risk task in air (F) and toluene (G) exposed rats. Note increase in signal during deliberation phase just prior to choice selection and change in activity during reward consumption. Unlike controls, toluene exposed animals showed no discrimination between a safe win (green trace) and a risky win (blue trace). Figure adapted from Braunscheidel et al., 2019 and used with persmission.