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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Curr Stem Cell Rep. 2022 Jul 14;8(3):139–149. doi: 10.1007/s40778-022-00214-z

Figure 1. Pediatric, young adult, geriatric, and JDO murine models of H-ARS.

Figure 1.

A) Mouse-human age equivalencies used to develop C57BL/6J H-ARS models. B) Groups of C57BL/6 pediatric mice at 3, 4, 5, 6, 7, or 8 weeks old, young adult mice at 3 months old, middle-aged mice at 1 year old, and geriatric mice at 2 years old, or JDO mice at 8 weeks old, were exposed to various doses of TBI, n=200-400 mice per age/strain, and day 30 survival at each dose was used to construct sex-combined DRR probit plots for each group with LD50/30 indicated. Slope and LD50/30 of 4-8-week-old C57BL/6J mice were similar (yellow highlight). C) Sex differences in LD50/30 with age in C57BL/6J mice (*p<0.05 for hazard ratio of death between sexes by Cox regression analysis). Data compiled from [60, 61, 130].