Table 1. Lag time intervals evaluated in systematic reviews and meta-analyses on the association between time to diagnosis and/or treatment and clinical outcomes, by cancer site.

Cancer site	Lag time interval*	First author (year), type of review
Brain	T30	Loureiro et al., 2016, meta-analysis
	T33	Warren et al., 2019, systematic review
Breast	T32	Yu et al., 2013, meta-analysis
	T30	Gupta et al., 2016, meta-analysis
	T32	Raphael et al., 2016, meta-analysis
	T32	Zhan et al., 2018, meta-analysis
Blood	T21	Zhao et al., 2019, meta-analysis
Colorectal	T32	Des Guetz et al., 2010, meta-analysis
	T32	Biagi et al., 2011, meta-analysis
	T29	Foster et al., 2013, systematic review
	T29	Wang et al., 2016, meta-analysis
	T29	Petrelli et al., 2016, meta-analysis
	T29	Du et al., 2018, meta-analysis
	T28	Wu et al., 2018, meta-analysis
	T18	Hangaard Hansen et al., 2018, meta-analysis
	T32	Petrelli et al., 2019, meta-analysis
Eye	T4	Mattosinho et al., 2019 meta-analysis
Head and neck	T4	Gómez et al., 2009, meta-analysis
	T1, T2, T4, T11	Seoane et al., 2012, meta-analysis
	T1, T2, T4, T11	Seoane et al., 2016, meta-analysis
	T29	Lin et al., 2016, meta-analysis
	T17, T30, T31	Graboyes et al., 2019, systematic review
Paediatric	T4	Brasme et al., 2012, systematic review
	T4	Lethaby et al., 2013, systematic review
Prostate	T18, T20	van den Bergh et al., 2013, systematic review
Ovarian	T32	Liu et al., 2017, meta-analysis
	T32	Usón et al., 2017, meta-analysis
Multisite	T1–T9, T11–T16, T18–T27	Neal et al., 2015, systematic review
	T10	Doubeni et al., 2018, systematic review

^*Lag time intervals correspond to those defined in Figure 2. Reviews on the same cancer site are sorted by publication year.