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. Author manuscript; available in PMC: 2023 Feb 14.
Published in final edited form as: Blood Rev. 2020 Jul 10;46:100732. doi: 10.1016/j.blre.2020.100732

Figure 4: Two of the Main Workflows for Mass Spectrometry of Monoclonal Protein in Multiple Myeloma.

Figure 4:

In the top workflow, intact light chains are tracked either by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) or liquid chromatography mass spectrometry (LC-MS) (basis for miRAMM assay utilized by Mills et al. [63] and Murray et al. [64]). The bottom workflow uses liquid chromatography tandem mass spectrometry (LC-MS/MS) to detect clonotypic peptides from the M-protein. Right panels show visualization of monoclonal protein readout for each technique.