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. 2023 Feb 13;12(1):2174721. doi: 10.1080/2162402X.2023.2174721

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Intracellular multicolor staining for cytokine- production (IFN-γ, TNF-α and IL-10), after 5h of anti-CD3 activation, in CD8⁺ (a-b), CD4⁺ (c-d) and B (e-f) cells, on 18 patients (Group1-3FRX, n = 5; Group2-20FRX, n = 6; Group3-30FRX, n = 7). (a, c, e) Dot-plots representing cytokine production in gated CD8⁺ (a), CD4⁺ (c) and B (e) cells, from two representative patients, at baseline (PRE) and treatment-end (END-RT). (b-d) Proportion of CD8⁺ (b) and CD4⁺ (d) producing IFN-γ (top panels) TNF-α (middle panels) and IL10 (bottom panels), during treatment (left panels) (Wilcoxon U-test). (f) Proportion of B cells producing IL10 during the treatment (Wilcoxon U-test). Right panels, comparison among Groups, (Mann-Whitney U-test). *p ≤ .05. Abbreviation: FRX = fraction; MP = Middle point; POST = 6 months after RT; ND = not determined.