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The top 10 hub genes of the significantly upregulated and downregulated DEMs by MCC.
| Upregulated | Downregulated | ||
|---|---|---|---|
| Gene | Score | Gene | Score |
| MMP9 | 3.29E + 09 | CCND1 | 6732 |
| EGFR | 3.28E + 09 | MTOR | 6489 |
| NOTCH1 | 3.17E + 09 | HSPA4 | 6422 |
| IL1B | 3.04E + 09 | FOS | 6047 |
| RHOA | 2.89E + 09 | MCL1 | 3675 |
| HSP90AA1 | 2.70E + 09 | ERBB2 | 3510 |
| CDH1 | 2.64E + 09 | CDKN1A | 3420 |
| IGF1R | 2.47E + 09 | CREB1 | 3335 |
| SMAD4 | 1.97E + 09 | MAPK1 | 3288 |
| CDC42 | 1.93E + 09 | AR | 3029 |
