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. 2023 Jan 16;25(2):351–365. doi: 10.1038/s41556-022-01064-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Left: schematic representation of the radial and proximal–distal airway-dependent axes. Right: spatial maps of the radial (top) and proximal–distal (bottom), scores of an 8.5 PCW lung section, analysed by ST. Colour indicates distance from epithelium (number of ST spots). Yellow, high; dark green, zero. Proximal–distal score as scaled aggregated expression of SOX2, SCGB3A2 (proximal) and ETV5, TPPP3 (distal). Proximal, −1; distal, 1. b, Heat maps of ASM-, AF- and AdvF-related cluster-density scores along the two analysed axes. Colour indicates relative cell frequency in the indicated position. Yellow, high; black, zero. c, Proximal–distal axis score of the epithelium of a 13 PCW lung section, analysed by HybISS. DAPI, grey; proximal, red; distal, blue. Scale bar, 1,000 µm. d, Density maps of ASM and AF clusters, showing their distribution along proximal–distal axis (y axis) and their distance from the epithelium (x axis), as in a and b. Colour indicates relative cell frequency in the indicated position. Yellow, high; black, zero.