Table 1.
Clinical patient characteristics and dosing information
| Breed | Sex | Age (years) | Weight (kg) | Dose (mg/m2) | Total Dose (mg) | Fractionation Schedule (days) | First/Last Dose (mg) | First/Last 4-OHCP AUC† (hr*ng/mL/mg) | |
|---|---|---|---|---|---|---|---|---|---|
| 1* | Mixed | FS | 13.1 | 25.8 | 233 | 200 | 4 | 50/50 | 7.8/11.8 |
| 2* | Lab | MC | 10.2 | 32.4 | 247.5 | 250 | 3 | 100/50 | 2.9/8.8 |
| 3 | Mixed | FS | 12.2 | 21.6 | 231 | 200 | 3 | 75/50 | 7.4/2.1 |
| 4 | Rhd Ridg | MC | 9.1 | 44.2 | 200 | 250 | 3 | 100/50 | 3.0/20.2 |
| 5* | Hound | FS | 4.3 | 64.2 | 247 | 400 | 4 | 100/100 | 6.4/5.4 |
| 6 | Collie | FS | 4.1 | 23.6 | 244 | 200 | 3 | 75/50 | 6.1/5.1 |
| 7 | BMD | FS | 6.0 | 44.9 | 238 | 300 | 3 | 100/100 | 7.9/1.9 |
| 8 | Bulldog | FS | 6.3 | 39.1 | 235 | 275 | 3 | 100/75 | 1.2/0.3 |
FS: female spayed; MC: male castrated; Lab: Labrador retriever, Rhd Ridg: Rhodesian Ridgeback; Hound: Bloodhound; BMD: Bernese Mountain Dog.
†
Dose-normalized values of AUC0-t calculated from non-compartmental PK analysis.
*
Patients for which Kel and t1/2 were calculable