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. 2022 Dec 9;41(5):1092–1104. doi: 10.1200/JCO.22.01453

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FIG 2. — Predicted cumulative prostate cancer risks for a 45-year-old consultand by combinations of family history and PGS percentile: (A) father diagnosed at age 50 years, by polygenic score; (B) father diagnosed at age 60 years, by polygenic score; (C) father diagnosed at age 70 years, by polygenic score; and (D) father diagnosed at age 80 years, by polygenic score. For comparison, all graphs show the population average risk (black curve). Consultands were assumed to be born after 1960 and fathers were assumed to be born in the 1930-1939 birth cohort. PGS, polygenic score.