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. 2022 Dec 9;41(5):1092–1104. doi: 10.1200/JCO.22.01453

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FIG 3. — Predicted cumulative prostate cancer risks for a 45-year-old consultand by combinations of family history, pathogenic variant, and PGS percentile: (A) BRCA2 pathogenic variant carrier, by family history and polygenic score percentile; (B) HOXB13 G84E carrier, by family history and polygenic score percentile; (C) BRCA1 pathogenic variant carrier, by family history and polygenic score percentile; and (D) noncarrier of pathogenic variants in BRCA2, HOXB13, and BRCA1, by family history and polygenic score percentile. For comparison, all graphs show the population average risk (black curve). Consultands were assumed to be born after 1960 and fathers were assumed to be born in the 1930-39 birth cohort. PGS, polygenic score.