FIGURE 4.

Chromosome microarray analysis of neoplastic cells identified complex DNA copy number aberrations. (A) There are mosaic losses (in 1p) and gains (in 1p and 1q) of chromosome 1, with copy number changes consistent with chromothripsis. (B) Chromosomes depicted by Karyoview with gains shown in blue and losses in red. There are segmental losses in 6q, 11p, 16q, and 17p, and gains in chromosomes 6p, 7, 8, and X. These changes may be useful to monitor clonal evolution and progression of the lymphoma cells