TABLE 1.

SNPs of the ALK gene of each tumour sample by RNA sequence analysis

Sample	Mutation of ALK gene	ClinVar	Nucleotide change	rs number
Small‐sized tumour cells at onset	D1529E	Benign	c.4587C > G	rs1881421
	K1491R	Benign	c.4472A > G	rs1881420
	I1461V	Benign	c.4381A > G	rs1670283
Large‐sized tumour cells at onset	D1529E	Benign	c.4587C > G	rs1881421
	K1491R	Benign	c.4472A > G	rs1881420
	I1461V	Benign	c.4381A > G	rs1670283
Small‐sized tumour cells at the first relapse	D1529E	Benign	c.4587C > G	rs1881421
	K1491R	Benign	c.4472A > G	rs1881420
	I1461V	Benign	c.4381A > G	rs1670283
Large‐sized tumour cells of the pulmonary tumour at the second relapse	L1196M	Likely pathogenic	c.3586C > A	rs1057519784
	D1529E	Benign	c.4587C > G	rs1881421
	K1491R	Benign	c.4472A > G	rs1881420
	I1461V	Benign	c.4381A > G	rs1670283

Note: Large tumour cells of the pulmonary tumour at the second relapse acquired an L1196M mutation in the ALK gene.

Abbreviation: SNPs, single nucleotide polymorphisms.