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. 2023 Feb 1;17:1090738. doi: 10.3389/fnana.2023.1090738

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Copyright © 2023 Elhessy, Habotta, Eldesoqui, Elsaed, Soliman, Sewilam, Elhassan and Lashine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical analysis of S100 marker in the control group (A), the model group (B), the Cerebrolysin group (C), the dexamethasone group (D), and vitamin C (E). Arrows point to positively stained cells. (F) Comparison of the expression between different groups. S100 expression was significantly decreased in the model group as compared to the control group. The Cerebrolysin group, dexamethasone group, and vitamin C cause a significant increase in S100 expression correlated with the model group. There was no significant difference between Cerebrolysin and dexamethasone. *Significance as compared to control, ^#significance as compared to the model, and ^$significance as compared to Vit C group.