Inclusion Criteria:
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1) |
18 years of age or older; |
2) |
with either ST-segment elevation myocardial infarction or non-ST-segment elevation myocardial infarction consistent with the Third Universal Definition of Myocardial Infarction and Type 1 (spontaneous), Type 2 (oxygen supply/demand mismatch), Type 4b (stent thrombosis at angiography), or Type 4c (in-stent restenosis)13 that occurs on admission or during the index hospitalization, |
3) |
with a hemoglobin concentration less than 10 g/dL at the time of random allocation, and |
4) |
4) the patient’s attending physician, with expertise in cardiovascular care, believes that both of the transfusion strategies are consistent with good medical care for the patient as determined by his/her clinical judgement. |
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Exclusion Criteria:
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1) |
uncontrolled acute bleeding at the time of randomization defined as the need for uncrossed or non-type specific blood; |
2) |
decline blood transfusion; |
3) |
scheduled for cardiac surgery during the current admission; |
4) |
are receiving only palliative treatment; |
5) |
if known that follow-up will not be possible at 30 days; |
6) |
if previously participated in MINT |
7) |
if currently enrolled in a competing study that interferes with the intervention or follow-up of MINT or enrolled in a competing study that has not been approved by the local IRB; or |
8) |
if the attending physician does not believe the patient is an appropriate candidate for the trial for any reason. |