Table 5.
Multivariate logistic regression analysis (Model 2 in Table 4) on associations of cutoff of nutritional indices with diagnosis of sarcopenia.
| Independent variable | ||||||||
|---|---|---|---|---|---|---|---|---|
| Albumin | GNRI | GNRI | CONUT | |||||
| Dependent variable | Cutoff: 4.20 | P | Cutoff: 98 | P | Cutoff: 105 | P | Cutoff: 2 | P |
| Men | ||||||||
| Low SMI | 1.51 (0.79–2.90) | 0.214 | 3.82 (1.52–9.57) | 0.004 | 9.84 (4.73–20.47) | < 0.001 | 1.10 (0.55–2.19) | 0.796 |
| Low hand grip strength | 1.86 (0.81–4.29) | 0.143 | 2.69 (0.99–7.31) | 0.053 | 2.48 (1.10–5.59) | 0.028 | 1.18 (0.51–2.75) | 0.699 |
| Low walking speed | 0.36 (0.07–1.97) | 0.236 | 1.54 (0.23–10.19) | 0.656 | 0.98 (1.18–5.23) | 0.983 | 0.94 (0.17–5.16) | 0.940 |
| Sarcopenia | 2.15 (0.76–6.13) | 0.151 | 3.76 (1.23–11.55) | 0.021 | 5.29 (1.90–14.68) | < 0.001 | 0.90 (0.32–2.56) | 0.843 |
| Independent variable | ||||||||
| Albumin | GNRI | GNRI | CONUT | |||||
| Dependent variable | Cutoff: 4.00 | P | Cutoff: 98 | P | Cutoff: 105 | P | Cutoff: 1 | P |
| Women | ||||||||
| Low SMI | 2.15 (0.93–4.95) | 0.073 | 5.29 (1.67–16.78) | 0.005 | 12.04 (4.98–29.14) | < 0.001 | 1.30 (0.52–3.26) | 0.575 |
| Low hand grip strength | 5.42 (2.30–12.77) | < 0.001 | 2.35 (0.73–7.53) | 0.152 | 1.44 (0.64–3.24) | 0.379 | 1.22 (0.52–2.87) | 0.645 |
| Low walking speed | 2.99 (0.84–10.67) | 0.093 | 0.84 (0.09–7.74) | 0.877 | 0.44 (0.09–2.23) | 0.321 | 0.71 (0.19–2.64) | 0.608 |
| Sarcopenia | 7.69 (2.21–26.67) | < 0.001 | 7.07 (1.75–28.58) | 0.006 | 7.71 (2.24–26.54) | < 0.001 | 0.58 (0.16–2.09) | 0.407 |
| Independent variable | ||||||||
| Albumin | GNRI | GNRI | CONUT | |||||
| Dependent variable | Cutoff: 3.70 | P | Cutoff: 98 | P | Cutoff: 102 | P | Cutoff: 1 | P |
| BMI<22 | ||||||||
| Low SMI | 0.22 (0.06–0.77) | 0.018 | 0.95 (0.41–2.21) | 0.907 | 1.11 (0.50-2.46) | 0.802 | 0.97 (0.37–2.56) | 0.958 |
| Low hand grip strength | 2.22 (0.59–8.35) | 0.240 | 3.51 (1.25–9.86) | 0.017 | 5.32 (1.61–17.56) | 0.006 | 0.55 (0.17–1.83) | 0.333 |
| Low walking speed | 9.42 (0.57–154.68) | 0.116 | 5.96 (0.46–76.65) | 0.171 | – | 0.24 (0.01–7.28) | 0.415 | |
| Sarcopenia | 0.86 (0.18–4.10) | 0.848 | 3.01 (0.10–9.08) | 0.051 | 7.73 (1.77–33.78) | 0.007 | 0.23 (0.05–0.97) | 0.045 |
| Low SMI | 1.18 (0.51–2.72) | 0.736 | 3.49 (0.29–42.05) | 0.326 | 11.69 (3.34–40.50) | < 0.001 | 0.74 (0.32–1.73) | 0.485 |
| Low hand grip strength | 3.44 (1.68–7.08) | < 0.001 | 6.59 (0.62–70.29) | 0.119 | 1.53 (0.74–3.16) | 0.250 | 1.60 (0.79–3.24) | 0.189 |
| Low walking speed | 1.80 (0.57–5.65) | 0.317 | – | 0.35 (0.11–1.13) | 0.079 | 1.14 (0.38–3.44) | 0.817 | |
| Sarcopenia | 2.56 (0.89–7.36) | 0.081 | 12.34 (0.72–212.73) | 0.084 | 7.15 (1.45–35.33) | 0.016 | 1.09 (0.37–3.22) | 0.873 |
| Independent variable | ||||||||
| Albumin | GNRI | GNRI | CONUT | |||||
| Dependent variable | Cutoff: 4.4 | P | Cutoff: 98 | P | Cutoff: 105 | P | Cutoff: 1 | P |
| Diabetes duration<5 years | ||||||||
| Low SMI | 0.08 (0.00–1.63) | 0.100 | – | 14.10 (0.93–214.6) | 0.057 | 34.1 (0.17–7,032.3) | 0.195 | |
| Low hand grip strength | 0.19 (0.01–3.61) | 0.269 | 12.46 (0.27–582.9) | 0.199 | – | – | ||
| Low walking speed | – | – | – | – | ||||
| Sarcopenia | 0.02 (0.00–2.65) | 0.113 | – | 67.23 (0.26–17,568.6) | 0.138 | – | ||
| Independent variable | ||||||||
| Albumin | GNRI | GNRI | CONUT | |||||
| Dependent variable | Cutoff: 4.00 | P | Cutoff: 98 | P | Cutoff: 105 | P | Cutoff: 3 | P |
| Diabetes duration ≥5 years | ||||||||
| Low SMI | 0.90 (0.48–1.70) | 0.752 | 4.73 (2.27–9.83) | < 0.001 | 9.39 (5.31–16.61) | < 0.001 | 1.67 (0.80–3.46) | 0.171 |
| Low hand grip strength | 2.89 (1.55–5.39) | < 0.001 | 2.31 (1.07–4.96) | 0.032 | 1.58 (0.87–2.85) | 0.131 | 1.46 (0.66–3.23) | 0.350 |
| Low walking speed | 1.97 (0.72–5.41) | 0.186 | 1.39 (0.36–5.40) | 0.635 | 0.68 (0.22–2.10) | 0.506 | 1.39 (0.39–4.91) | 0.612 |
| Sarcopenia | 2.71 (1.23–5.98) | 0.014 | 5.20 (2.15–12.60) | < 0.001 | 5.55 (2.51–12.30) | < 0.001 | 1.76 (0.63–4.94) | 0.280 |
Data are odds ratio (95% confidential intervals) as Model 2 in Table 4 corrected for age (years), sex, diabetes duration (years), HbA1c (%), and eGFR (ml/min/1.73 m2).
GNRI, geriatric nutritional risk index; CONUT, controlling nutritional status; P, provability; SMI, skeletal mass index; BMI, skeletal mass index.