Table 2.
Characteristics and quality assessment of included cost-utility analyses for cancer treatment
| CUAs included [n = 467] | CUAs that used disutilities of AEs [n = 254, 54%] | CUAs that did not use disutilities of AEs [n = 213, 46%] | |
|---|---|---|---|
| Year of publication | |||
| 2019 | 107 (23) | 51 (48) | 56 (52) |
| 2020 | 129 (28) | 65 (50) | 64 (50) |
| 2021 | 190 (41) | 116 (61) | 74 (39) |
| 2022 | 41 (9) | 22 (54) | 19 (46) |
| Countrya | |||
| United States | 196 (42) | 115 (59) | 81 (41) |
| China | 129 (28) | 62 (48) | 67 (52) |
| Canada | 28 (6) | 17 (61) | 11 (39) |
| Japan | 15 (3) | 9 (60) | 6 (40) |
| UK | 16 (3) | 9 (56) | 7 (44) |
| Othersb | 110 (24) | 55 (50) | 55 (50) |
| Study population | |||
| Non-small cell lung cancer | 103 (22) | 63 (61) | 40 (39) |
| Hematological malignancies | 86 (18) | 50 (58) | 36 (42) |
| Breast cancer | 62 (13) | 30 (48) | 32 (52) |
| Melanoma | 24 (5) | 16 (67) | 8 (33) |
| Prostate cancer | 21 (5) | 16 (76) | 5 (24) |
| Hepatocellular carcinoma | 26 (6) | 15 (58) | 11 (42) |
| Colorectal cancer | 28 (6) | 11 (39) | 17 (61) |
| Othersc | 117 (25) | 53 (45) | 64 (55) |
| Study perspectived | |||
| Health care payer | 401 (86) | 231 (58) | 170 (42) |
| Society | 52 (11) | 19 (37) | 33 (63) |
| Otherse | 3 (1) | 0 (0) | 3 (100) |
| Not stated | 16 (3) | 9 (56) | 7 (44) |
| Model structuref | |||
| Markov model | 263 (56) | 129 (49) | 134 (51) |
| Partitioned survival model | 152 (33) | 101 (66) | 51 (34) |
| Othersg | 44 (9) | 24 (55) | 20 (45) |
| Not stated | 13 (3) | 3 (23) | 10 (77) |
| Quality score | |||
| 100 | 96 (21) | 56 (58) | 40 (42) |
| 75–99 | 359 (77) | 194 (54) | 165 (46) |
| 74–50 | 12 (3) | 4 (33) | 8 (67) |
Data are expressed as n (%)
CUAs cost-utility analyses
aMultiple countries were studied in some CUAs
bFrance, The Netherlands, Australia, Singapore, Italy, etc.
cLymphoma, leukemia, multiple myeloma, head and neck squamous cell carcinoma, renal cell carcinoma, pancreatic cancer, small cell lung cancer, etc.
dMultiple perspectives were studied in some CUAs
eHospital or patient perspective
fMultiple models were applied in some CUAs
gDecision tree and Markov model, decision tree model, discrete event simulation model, etc.