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. 2023 Feb 8;7:e2200336. doi: 10.1200/PO.22.00336

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FIG 5. — Case (patient 9067) exemplifying parallel evolution in GEP-NEC. Mutations are drawn in an assumed phylogenetic tree, based in molecular data from patient 9067. Gray line (trunk) indicates the (presumably early) mutations shared between solid and liquid biopsy, while the red lines (branches) indicate mutations uniquely detected in the liquid biopsy. As one of two patients with PTEN mutations uniquely detected in liquid biopsy, among the 50 analyzed cases, patient 9067 had five different parallel PTEN mutations detected in liquid biopsy. GEP-NEC, gastroenteropancreatic neuroendocrine carcinoma.