TABLE 2.

Characteristics of stratified patient groups in the in vivo cohort

	Total sample (N = 242)	LATE-NC–like (N = 25)	AD-like (N = 77)
Age (years)	74.9 ± 8.0	81.2 ± 6.2	71.4 ± 8.1
Sex (M/F)	143/99	15/10	41/36
Education (years)	15.3 ± 2.9	15.1 ± 3.1	15.6 ± 2.6
MMSE	23.2 ± 2.1	23.1 ± 2.0	23.0 ± 2.1
MEM	−0.89 ± 0.53	−0.75 ± 0.46	−1.03 ± 0.53
EXEC	−0.92 ± 0.93	−0.54 ± 0.80	−1.24 ± 0.88
Δ(MEM-EXEC)	0.03 ± 0.80	−0.20 ± 0.79	0.21 ± 0.77
CSF Aβ42 (pg/ml)	704 ± 433	1283 ± 822	625 ± 263
CSF p-tau181 (pg/ml)	37 ± 16	31 ± 16	41 ± 16
APOE, 0/1/2 ε4 alleles, %pos	82/112/47, 66%	13/12/0, 48%	25/36/16, 68%
TMEM106B, 0/1/2 T alleles, % pos	36/105/69, 83%	2/8/11, 91%	13/38/20, 82%
GRN, 0/1/2 T alleles, % pos	104/80/26, 51%	8/8/5, 62%	31/32/8, 56%

Abbreviations: AD, Alzheimer’s disease; APOE, apolipoprotein E; CSF, cerebrospinal fluid; EXEC, executive function composite score; F, female; LATE-NC, limbic age-related TDP-43 encephalopathy neuropathologic change; M, male; MEM, memory composite score; MMSE, Mini-Mental State Examination; N, sample size.

Notes: Significant differences (at P < 0.05) between LATE-NC–like and AD-like groups are printed in bold, differences with trend-level statistical significance (P < 0.1) are printed in italics.