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. 2023 Feb 14;14:822. doi: 10.1038/s41467-023-36310-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Scheme of the experimental design and analytical workflow of this study for scRNA-seq. b Validation experiment based on patient-derived organoids from ascites. c Uniform Manifold Approximation and Projection (UMAP) plot showing the main cell types from all samples. Each cluster is colored and annotated according to cell type. Mono/Macro, monocyte/macrophage; cDC1, type 1 conventional dendritic cells; cDC2, type 2 conventional dendritic cells. d Heatmap showing z-score normalized mean expression of selected marker genes in each cell type. e The proportion of each cell type in different groups from G0 (n = 4 samples), G1 (n = 4 samples), G2 (n = 10 samples) and G3 (n = 12 samples) Group. Histogram colors correspond to cell type colors in c; point colors correspond to samples. Data are presented as mean values ± SEM (error bars); the p-values are calculated by one-way ANOVA test. f UMAP plot representing myeloid cell clusters colored by cluster. DC dendritic cell, Macro macrophage, Mono monocyte. g Heatmap showing z-score normalized mean expression of selected genes in each cluster of myeloid cells. h The proportion of each cluster of myeloid cells from G0 (n = 4 samples), G1 (n = 4 samples), G2 (n = 10 samples) and G3 (n = 12 samples) Groups. Histogram colors correspond to cell type colors in f; point colors correspond to samples. Data are presented as mean values ± SEM (error bars); the p-values are calculated by two-sided unpaired Student’s t-test. Source data are provided as a Source Data file.